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Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.

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Title: Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.
Authors: Lin J; Department of Pathology, UCSD, La Jolla, California, USA., Callender JA; Department of Pathology, UCSD, La Jolla, California, USA., Mayfield JE; Department of Pathology, UCSD, La Jolla, California, USA., McClatchy DB; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Ojeda-Juárez D; Department of Pathology, UCSD, La Jolla, California, USA., Pourhamzeh M; Department of Pathology, UCSD, La Jolla, California, USA., Soldau K; Department of Pathology, UCSD, La Jolla, California, USA., Kurt TD; Department of Pathology, UCSD, La Jolla, California, USA., Danque GA; Department of Pathology, UCSD, La Jolla, California, USA., Khuu H; Department of Pathology, UCSD, La Jolla, California, USA., Ronson JE; Department of Pathology, UCSD, La Jolla, California, USA., Pizzo DP; Department of Pathology, UCSD, La Jolla, California, USA., Du Y; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Gruber MA; Department of Pathology, UCSD, La Jolla, California, USA., Sevillano AM; Department of Pathology, UCSD, La Jolla, California, USA., Wang J; Department of Pathology, UCSD, La Jolla, California, USA., Orrú CD; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA., Chen J; Department of Pathology, UCSD, La Jolla, California, USA., Funk G; Department of Pathology, UCSD, La Jolla, California, USA., Aguilar-Calvo P; Department of Pathology, UCSD, La Jolla, California, USA., Aulston BD; Department of Pathology, UCSD, La Jolla, California, USA., Roy S; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Rho JM; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Bui JD; Department of Pathology, UCSD, La Jolla, California, USA., Newton AC; Department of Pharmacology, UCSD, La Jolla, California, USA., Lipton SA; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.; Neurodegeneration New Medicines Center and Department of Molecular & Cellular Biology, The Scripps Research Institute, La Jolla, California, USA., Caughey B; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA., Patrick GN; Department of Biology, and., Doré K; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Yates JR 3rd; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Sigurdson CJ; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Pathology, Microbiology, and Immunology, UCD, Davis, California, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Apr 04; Vol. 135 (10). Date of Electronic Publication: 2025 Apr 04 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.
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  Data: <searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Callender+JA%22">Callender JA</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Mayfield+JE%22">Mayfield JE</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22McClatchy+DB%22">McClatchy DB</searchLink>; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Ojeda-Juárez+D%22">Ojeda-Juárez D</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Pourhamzeh+M%22">Pourhamzeh M</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Soldau+K%22">Soldau K</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Kurt+TD%22">Kurt TD</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Danque+GA%22">Danque GA</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Khuu+H%22">Khuu H</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Ronson+JE%22">Ronson JE</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Pizzo+DP%22">Pizzo DP</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Du+Y%22">Du Y</searchLink>; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Gruber+MA%22">Gruber MA</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Sevillano+AM%22">Sevillano AM</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Orrú+CD%22">Orrú CD</searchLink>; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Funk+G%22">Funk G</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Aguilar-Calvo+P%22">Aguilar-Calvo P</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Aulston+BD%22">Aulston BD</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Roy+S%22">Roy S</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Rho+JM%22">Rho JM</searchLink>; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Bui+JD%22">Bui JD</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Newton+AC%22">Newton AC</searchLink>; Department of Pharmacology, UCSD, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Lipton+SA%22">Lipton SA</searchLink>; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.; Neurodegeneration New Medicines Center and Department of Molecular & Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Caughey+B%22">Caughey B</searchLink>; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+GN%22">Patrick GN</searchLink>; Department of Biology, and.<br /><searchLink fieldCode="AU" term="%22Doré+K%22">Doré K</searchLink>; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Yates+JR+3rd%22">Yates JR 3rd</searchLink>; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Sigurdson+CJ%22">Sigurdson CJ</searchLink>; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Pathology, Microbiology, and Immunology, UCD, Davis, California, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Apr 04; Vol. 135 (10). <i>Date of Electronic Publication: </i>2025 Apr 04 (<i>Print Publication: </i>2025).
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