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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.

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Title: Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.
Authors: Neiens V; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Hansbauer EM; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Jaquin TJ; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Peper-Gabriel JK; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Mahavadi P; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany., Snyder ME; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Starzl Transplantation Institute, Pittsburgh, PA, 15213, USA., Grill MJ; Ebenbuild GmbH, 80469, Munich, Germany., Wurzenberger C; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Konitsiotis A; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Estrada-Bernal A; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Heinig K; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Fysikopoulos A; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Schwenck N; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Grüner S; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Bartoschek D; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Mosebach T; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Kerstan S; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Wrennall J; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA., Richter M; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Noda K; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Hoetzenecker K; Department of Thoracic Surgery Vienna, Medical University of Vienna, 1090, Vienna, Austria., Burgess JK; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ, Groningen, the Netherlands., Tarran R; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA., Wurzenberger C; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Wichmann KR; Ebenbuild GmbH, 80469, Munich, Germany., Biehler J; Ebenbuild GmbH, 80469, Munich, Germany., Müller KW; Ebenbuild GmbH, 80469, Munich, Germany., Guenther A; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany.; Agaplesion Evangelisches Krankenhaus Mittelhessen, 35398, Giessen, Germany.; European IPF Network and European IPF Registry, 35392, Giessen, Germany.; Member of the Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany., Eickelberg O; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Fitzgerald MF; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Olwill SA; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Matschiner G; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Pavlidou M; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany. marinapavlidou5@gmail.com.
Source: Nature communications [Nat Commun] 2025 Apr 05; Vol. 16 (1), pp. 3251. Date of Electronic Publication: 2025 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-58568-x