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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.

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Title: Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.
Authors: Neiens V; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Hansbauer EM; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Jaquin TJ; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Peper-Gabriel JK; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Mahavadi P; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany., Snyder ME; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Starzl Transplantation Institute, Pittsburgh, PA, 15213, USA., Grill MJ; Ebenbuild GmbH, 80469, Munich, Germany., Wurzenberger C; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Konitsiotis A; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Estrada-Bernal A; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Heinig K; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Fysikopoulos A; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Schwenck N; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Grüner S; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Bartoschek D; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Mosebach T; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Kerstan S; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Wrennall J; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA., Richter M; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Noda K; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Hoetzenecker K; Department of Thoracic Surgery Vienna, Medical University of Vienna, 1090, Vienna, Austria., Burgess JK; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ, Groningen, the Netherlands., Tarran R; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA., Wurzenberger C; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Wichmann KR; Ebenbuild GmbH, 80469, Munich, Germany., Biehler J; Ebenbuild GmbH, 80469, Munich, Germany., Müller KW; Ebenbuild GmbH, 80469, Munich, Germany., Guenther A; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany.; Agaplesion Evangelisches Krankenhaus Mittelhessen, 35398, Giessen, Germany.; European IPF Network and European IPF Registry, 35392, Giessen, Germany.; Member of the Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany., Eickelberg O; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Fitzgerald MF; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Olwill SA; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Matschiner G; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany., Pavlidou M; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany. marinapavlidou5@gmail.com.
Source: Nature communications [Nat Commun] 2025 Apr 05; Vol. 16 (1), pp. 3251. Date of Electronic Publication: 2025 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.
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  Data: <searchLink fieldCode="AU" term="%22Neiens+V%22">Neiens V</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Hansbauer+EM%22">Hansbauer EM</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Jaquin+TJ%22">Jaquin TJ</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Peper-Gabriel+JK%22">Peper-Gabriel JK</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Mahavadi+P%22">Mahavadi P</searchLink>; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Snyder+ME%22">Snyder ME</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Starzl Transplantation Institute, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Grill+MJ%22">Grill MJ</searchLink>; Ebenbuild GmbH, 80469, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wurzenberger+C%22">Wurzenberger C</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Konitsiotis+A%22">Konitsiotis A</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Estrada-Bernal+A%22">Estrada-Bernal A</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Heinig+K%22">Heinig K</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Fysikopoulos+A%22">Fysikopoulos A</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Schwenck+N%22">Schwenck N</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Grüner+S%22">Grüner S</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Bartoschek+D%22">Bartoschek D</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Mosebach+T%22">Mosebach T</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Kerstan+S%22">Kerstan S</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Wrennall+J%22">Wrennall J</searchLink>; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Noda+K%22">Noda K</searchLink>; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Hoetzenecker+K%22">Hoetzenecker K</searchLink>; Department of Thoracic Surgery Vienna, Medical University of Vienna, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Burgess+JK%22">Burgess JK</searchLink>; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tarran+R%22">Tarran R</searchLink>; University of North Carolina Department of Cell Biology & Physiology, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22Wurzenberger+C%22">Wurzenberger C</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Wichmann+KR%22">Wichmann KR</searchLink>; Ebenbuild GmbH, 80469, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Biehler+J%22">Biehler J</searchLink>; Ebenbuild GmbH, 80469, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+KW%22">Müller KW</searchLink>; Ebenbuild GmbH, 80469, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Guenther+A%22">Guenther A</searchLink>; Department of Internal Medicine, Justus Liebig University (JLU) Giessen, 35392, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, 35392, Giessen, Germany.; Agaplesion Evangelisches Krankenhaus Mittelhessen, 35398, Giessen, Germany.; European IPF Network and European IPF Registry, 35392, Giessen, Germany.; Member of the Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Eickelberg+O%22">Eickelberg O</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+MF%22">Fitzgerald MF</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Olwill+SA%22">Olwill SA</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Matschiner+G%22">Matschiner G</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany.<br /><searchLink fieldCode="AU" term="%22Pavlidou+M%22">Pavlidou M</searchLink>; Pieris Pharmaceuticals GmbH, 85399, Hallbergmoos, Germany. marinapavlidou5@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Apr 05; Vol. 16 (1), pp. 3251. <i>Date of Electronic Publication: </i>2025 Apr 05.
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