View in EDS HTML Full Text PDF Full Text

A Randomized clinical trial evaluating the impact on survival and quality of life of 177Lutetium[Lu]-edotreotide versus everolimus in patients with neuroendocrine tumors of the lung and thymus: the LEVEL study (GETNE T-2217).

Saved in:
Bibliographic Details
Title: A Randomized clinical trial evaluating the impact on survival and quality of life of 177Lutetium[Lu]-edotreotide versus everolimus in patients with neuroendocrine tumors of the lung and thymus: the LEVEL study (GETNE T-2217).
Authors: Capdevila J; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain. jcapdevila@vhio.net., Pubul V; Department of Nuclear Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain., Anido U; Molecular Imaging Research Group, Nuclear Medicine Department, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Walter T; Medical Oncology Department, Edouard Herriot Hospital, Lyon, France., Molina-Cerrillo J; Medical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., Alonso-Gordoa T; Medical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., Garcia-Carbonero R; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.; Center of Experimental Oncology. Gastrointestinal and Neuroendrocrine Tumors Research Group. Hospital 12 de Octubre Research Institute (Imas12), Madrid, Spain.; Facultad de Medicina, Departamento de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain., San-Roman-Gil M; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Llana B; Nuclear Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain., Jimenez-Fonseca P; Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Oviedo, Spain., Benavent Viñuales M; Medical Oncology Department, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain., Ansquer C; Service de Médecine Nucléaire, CHU de Nantes, Nantes Université, Nantes, France., Baudin E; Department of Endocrine Oncology and Nuclear Medicine, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France., Lepage C; Department of Digestive Oncology, University Hospital Dijon, University of Burgundy and Franche Comté, Dijon, France., Del Olmo-García M; Endocrinology and Nutrition Department, Endocrinology, Nutrition and Diet Therapy Research Unit, University and Polytechnic Hospital La Fe, Valencia, Spain.; Departamento de Medicina, Universidad de Valencia, Valencia, Spain., Ruffinelli JC; Medical Oncology Department, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain., Beron A; Service de Médecine Nucléaire, Hôpital Claude Huriez, CHU Lille, Lille, France., Haissaguerre M; Department of Endocrinology, University of Bordeaux, Bordeaux, France., Deshayes E; Department of Nuclear Medicine, Institut du Cancer de Montpellier, Université de Montpellier, Cedex 5, Montpellier, France., Taïeb D; Department of Nuclear Medicine, Aix-Marseille University, La Timone University Hospital, Marseille, France., Baldari S; Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, Messina, Italy., Sansovini M; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) ''Dino Amadori'', Meldola, Italy., Cingarlini S; Medical Oncology, University and Hospital Trust of Verona, Verona, Italy., Filice A; Servizio Di Medicina Nucleare, Azienda USL-IRCCS Di Reggio Emilia, Reggio Emilia, Italy., Panzuto F; Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, Rome, Italy., Álvarez-Álvarez R; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Lousberg L; Service d'Oncologie Médicale CHU Liège, Liège, Belgium., Aboubakar Nana F; Department of Pulmonology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200, Brussels, Belgium.; Institut de Recherche Expérimentale Et Clinique (IREC), Université Catholique de Louvain, 1200, Brussels, Belgium., Hernando J; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain., García-Álvarez A; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain., García-Burillo A; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain., Villacampa G; Statistics Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Vandamme T; Department of Oncology and Netwerk, University Hospital Antwerp, Edegem, Belgium.; Center for Oncological Research, Integrated Personalized &Precision Oncology Network (IPPON), University of Antwerp, Wilrijk, Belgium., Fazio N; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy., Durand A; Medical Oncology Department, Edouard Herriot Hospital, Lyon, France.
Source: BMC cancer [BMC Cancer] 2025 Apr 04; Vol. 25 (1), pp. 613. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40186126
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Randomized clinical trial evaluating the impact on survival and quality of life of <superscript>177</superscript>Lutetium[Lu]-edotreotide versus everolimus in patients with neuroendocrine tumors of the lung and thymus: the LEVEL study (GETNE T-2217).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Capdevila+J%22">Capdevila J</searchLink>; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain. jcapdevila@vhio.net.<br /><searchLink fieldCode="AU" term="%22Pubul+V%22">Pubul V</searchLink>; Department of Nuclear Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Anido+U%22">Anido U</searchLink>; Molecular Imaging Research Group, Nuclear Medicine Department, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Walter+T%22">Walter T</searchLink>; Medical Oncology Department, Edouard Herriot Hospital, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Molina-Cerrillo+J%22">Molina-Cerrillo J</searchLink>; Medical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso-Gordoa+T%22">Alonso-Gordoa T</searchLink>; Medical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Carbonero+R%22">Garcia-Carbonero R</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.; Center of Experimental Oncology. Gastrointestinal and Neuroendrocrine Tumors Research Group. Hospital 12 de Octubre Research Institute (Imas12), Madrid, Spain.; Facultad de Medicina, Departamento de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22San-Roman-Gil+M%22">San-Roman-Gil M</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Llana+B%22">Llana B</searchLink>; Nuclear Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Jimenez-Fonseca+P%22">Jimenez-Fonseca P</searchLink>; Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Benavent+Viñuales+M%22">Benavent Viñuales M</searchLink>; Medical Oncology Department, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Ansquer+C%22">Ansquer C</searchLink>; Service de Médecine Nucléaire, CHU de Nantes, Nantes Université, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Baudin+E%22">Baudin E</searchLink>; Department of Endocrine Oncology and Nuclear Medicine, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lepage+C%22">Lepage C</searchLink>; Department of Digestive Oncology, University Hospital Dijon, University of Burgundy and Franche Comté, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Del+Olmo-García+M%22">Del Olmo-García M</searchLink>; Endocrinology and Nutrition Department, Endocrinology, Nutrition and Diet Therapy Research Unit, University and Polytechnic Hospital La Fe, Valencia, Spain.; Departamento de Medicina, Universidad de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ruffinelli+JC%22">Ruffinelli JC</searchLink>; Medical Oncology Department, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Beron+A%22">Beron A</searchLink>; Service de Médecine Nucléaire, Hôpital Claude Huriez, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Haissaguerre+M%22">Haissaguerre M</searchLink>; Department of Endocrinology, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Deshayes+E%22">Deshayes E</searchLink>; Department of Nuclear Medicine, Institut du Cancer de Montpellier, Université de Montpellier, Cedex 5, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Taïeb+D%22">Taïeb D</searchLink>; Department of Nuclear Medicine, Aix-Marseille University, La Timone University Hospital, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Baldari+S%22">Baldari S</searchLink>; Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Sansovini+M%22">Sansovini M</searchLink>; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) ''Dino Amadori'', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Cingarlini+S%22">Cingarlini S</searchLink>; Medical Oncology, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Filice+A%22">Filice A</searchLink>; Servizio Di Medicina Nucleare, Azienda USL-IRCCS Di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Panzuto+F%22">Panzuto F</searchLink>; Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Álvarez-Álvarez+R%22">Álvarez-Álvarez R</searchLink>; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lousberg+L%22">Lousberg L</searchLink>; Service d'Oncologie Médicale CHU Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Aboubakar+Nana+F%22">Aboubakar Nana F</searchLink>; Department of Pulmonology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200, Brussels, Belgium.; Institut de Recherche Expérimentale Et Clinique (IREC), Université Catholique de Louvain, 1200, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Hernando+J%22">Hernando J</searchLink>; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Álvarez+A%22">García-Álvarez A</searchLink>; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Burillo+A%22">García-Burillo A</searchLink>; Medical Oncology Department. Vall, Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Villacampa+G%22">Villacampa G</searchLink>; Statistics Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vandamme+T%22">Vandamme T</searchLink>; Department of Oncology and Netwerk, University Hospital Antwerp, Edegem, Belgium.; Center for Oncological Research, Integrated Personalized &Precision Oncology Network (IPPON), University of Antwerp, Wilrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Fazio+N%22">Fazio N</searchLink>; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Durand+A%22">Durand A</searchLink>; Medical Oncology Department, Edouard Herriot Hospital, Lyon, France.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100967800%22">BMC cancer</searchLink> [BMC Cancer] 2025 Apr 04; Vol. 25 (1), pp. 613. <i>Date of Electronic Publication: </i>2025 Apr 04.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial Protocol; Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100967800 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2407 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712407%22">14712407 </searchLink><i>NLM ISO Abbreviation: </i>BMC Cancer <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40186126
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s12885-025-13941-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 613
    Titles:
      – TitleFull: A Randomized clinical trial evaluating the impact on survival and quality of life of 177Lutetium[Lu]-edotreotide versus everolimus in patients with neuroendocrine tumors of the lung and thymus: the LEVEL study (GETNE T-2217).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Capdevila J
      – PersonEntity:
          Name:
            NameFull: Pubul V
      – PersonEntity:
          Name:
            NameFull: Anido U
      – PersonEntity:
          Name:
            NameFull: Walter T
      – PersonEntity:
          Name:
            NameFull: Molina-Cerrillo J
      – PersonEntity:
          Name:
            NameFull: Alonso-Gordoa T
      – PersonEntity:
          Name:
            NameFull: Garcia-Carbonero R
      – PersonEntity:
          Name:
            NameFull: San-Roman-Gil M
      – PersonEntity:
          Name:
            NameFull: Llana B
      – PersonEntity:
          Name:
            NameFull: Jimenez-Fonseca P
      – PersonEntity:
          Name:
            NameFull: Benavent Viñuales M
      – PersonEntity:
          Name:
            NameFull: Ansquer C
      – PersonEntity:
          Name:
            NameFull: Baudin E
      – PersonEntity:
          Name:
            NameFull: Lepage C
      – PersonEntity:
          Name:
            NameFull: Del Olmo-García M
      – PersonEntity:
          Name:
            NameFull: Ruffinelli JC
      – PersonEntity:
          Name:
            NameFull: Beron A
      – PersonEntity:
          Name:
            NameFull: Haissaguerre M
      – PersonEntity:
          Name:
            NameFull: Deshayes E
      – PersonEntity:
          Name:
            NameFull: Taïeb D
      – PersonEntity:
          Name:
            NameFull: Baldari S
      – PersonEntity:
          Name:
            NameFull: Sansovini M
      – PersonEntity:
          Name:
            NameFull: Cingarlini S
      – PersonEntity:
          Name:
            NameFull: Filice A
      – PersonEntity:
          Name:
            NameFull: Panzuto F
      – PersonEntity:
          Name:
            NameFull: Álvarez-Álvarez R
      – PersonEntity:
          Name:
            NameFull: Lousberg L
      – PersonEntity:
          Name:
            NameFull: Aboubakar Nana F
      – PersonEntity:
          Name:
            NameFull: Hernando J
      – PersonEntity:
          Name:
            NameFull: García-Álvarez A
      – PersonEntity:
          Name:
            NameFull: García-Burillo A
      – PersonEntity:
          Name:
            NameFull: Villacampa G
      – PersonEntity:
          Name:
            NameFull: Vandamme T
      – PersonEntity:
          Name:
            NameFull: Fazio N
      – PersonEntity:
          Name:
            NameFull: Durand A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 04
              M: 04
              Text: 2025 Apr 04
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1471-2407
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: BMC cancer
              Type: main
ResultId 1