Mechanisms of hematopoietic clonal dominance in VEXAS syndrome.

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Title: Mechanisms of hematopoietic clonal dominance in VEXAS syndrome.
Authors: Molteni R; Vita-Salute San Raffaele University, Milan, Italy. molteni.raffaella@hsr.it.; Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy. molteni.raffaella@hsr.it., Fiumara M; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Campochiaro C; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Alfieri R; National Research Council, Institute for Biomedical Technologies, Segrate, Italy., Pacini G; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Licari E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Tomelleri A; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Diral E; Unit of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy., Varesi A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Weber A; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Quaranta P; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Albano L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gaddoni C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Basso-Ricci L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Stefanoni D; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Alessandrini L; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Degl'Innocenti S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sanvito F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Bergonzi GM; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy., Annoni A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Panigada M; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cantoni E; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Canarutto D; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy., Xie SZ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Denver, CO, USA., Di Micco R; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; University School of Advanced Studies IUSS, Pavia, Italy., Aiuti A; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ciceri F; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy., De Luca G; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Dagna L; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Matucci-Cerinic M; Vita-Salute San Raffaele University, Milan, Italy.; Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merelli I; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; National Research Council, Institute for Biomedical Technologies, Segrate, Italy., Cenci S; Vita-Salute San Raffaele University, Milan, Italy.; Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scala S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cavalli G; Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Translational Medicine, Novartis Pharma, Basel, Switzerland., Naldini L; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ferrari S; Vita-Salute San Raffaele University, Milan, Italy. ferrari.samuele@hsr.it.; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. ferrari.samuele@hsr.it.
Source: Nature medicine [Nat Med] 2025 Jun; Vol. 31 (6), pp. 1911-1924. Date of Electronic Publication: 2025 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-03623-9