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Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.

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Title: Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.
Authors: Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Kundu J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Miller P; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Khan MS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Salinas J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., LeBlanc S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Nguyen T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Peng H; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Egli M; Department of Biochemistry, Vanderbilt University, School of Medicine Nashville, TN 37232, USA., Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Apr 29; Vol. 61 (36), pp. 6659-6662. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1364-548X
DOI:10.1039/d5cc00348b