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Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.

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Title: Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.
Authors: Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Kundu J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Miller P; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Khan MS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Salinas J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., LeBlanc S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Nguyen T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Peng H; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com., Egli M; Department of Biochemistry, Vanderbilt University, School of Medicine Nashville, TN 37232, USA., Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Apr 29; Vol. 61 (36), pp. 6659-6662. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.
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  Data: <searchLink fieldCode="AU" term="%22Datta+D%22">Datta D</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Kundu+J%22">Kundu J</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Miller+P%22">Miller P</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Khan+MS%22">Khan MS</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Salinas+J%22">Salinas J</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22LeBlanc+S%22">LeBlanc S</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Peng+H%22">Peng H</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Theile+CS%22">Theile CS</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Egli+M%22">Egli M</searchLink>; Department of Biochemistry, Vanderbilt University, School of Medicine Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Manoharan+M%22">Manoharan M</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com.
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  Data: <searchLink fieldCode="JN" term="%229610838%22">Chemical communications (Cambridge, England)</searchLink> [Chem Commun (Camb)] 2025 Apr 29; Vol. 61 (36), pp. 6659-6662. <i>Date of Electronic Publication: </i>2025 Apr 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9610838 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1364-548X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213597345%22">13597345 </searchLink><i>NLM ISO Abbreviation: </i>Chem Commun (Camb) <i>Subsets: </i>MEDLINE
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