Subclonal response heterogeneity to define cancer organoid therapeutic sensitivity.
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| Title: | Subclonal response heterogeneity to define cancer organoid therapeutic sensitivity. |
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| Authors: | Kratz JD; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Rehman S; Morgridge Institute for Research, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Johnson KA; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, USA., Gillette AA; Morgridge Institute for Research, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Sunil A; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Favreau PF; Morgridge Institute for Research, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Pasch CA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Miller D; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Zarling LC; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Yeung AH; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Clipson L; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, USA., Anderson SJ; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Steimle AK; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Sprackling CM; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Lemmon KK; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Abbott DE; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Burkard ME; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Bassetti MF; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Eickhoff JC; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Foley EF; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Heise CP; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Kimple RJ; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Lawson EH; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., LoConte NK; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Lubner SJ; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Mulkerin DL; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Matkowskyj KA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Sanger CB; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Uboha NV; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Mcilwain SJ; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Ong IM; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Carchman EH; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, USA.; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA., Skala MC; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Deming DA; Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin, Madison, WI, USA. ddeming@medicine.wisc.edu.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. ddeming@medicine.wisc.edu.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA. ddeming@medicine.wisc.edu.; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, USA. ddeming@medicine.wisc.edu. |
| Source: | Scientific reports [Sci Rep] 2025 Apr 09; Vol. 15 (1), pp. 12072. Date of Electronic Publication: 2025 Apr 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-96204-2 |
