Rational design of alternative treatment options for radioresistant rectal cancer using patient-derived organoids.

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Title: Rational design of alternative treatment options for radioresistant rectal cancer using patient-derived organoids.
Authors: Andel D; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Nouwens AJ; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Klaassen S; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Laoukili J; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Viergever B; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Verheem A; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Intven MPW; Department of Radiation Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Zandvliet M; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Hagendoorn J; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Borel Rinkes IHM; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl., Kranenburg O; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.
Source: British journal of cancer [Br J Cancer] 2025 Jun; Vol. 132 (10), pp. 973-981. Date of Electronic Publication: 2025 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-1827
DOI:10.1038/s41416-025-02989-4