Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.

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Bibliographic Details
Title: Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.
Authors: El Hebieshy AF; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl.; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl., Wijfjes Z; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Institute for Chemical Immunology, Nijmegen, the Netherlands., Le Gall CM; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Middelburg J; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., de Roode KE; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Tagworks Pharmaceuticals, Nijmegen, the Netherlands., Fennemann FL; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Sluijter M; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., van Hall T; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Dijkstra DJ; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., van Dalen FJ; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Rodgers Furones A; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., van der Schoot JMS; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Derksen I; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., de Haard H; Argenx BV, Gent, Belgium., van der Woning B; Argenx BV, Gent, Belgium., Talavera Ormeño CMP; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., van Doodewaerd BR; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Figdor CG; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., van der Heden van Noort GJ; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Parren PWHI; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., Heskamp S; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Ovaa H; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Verdoes M; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Institute for Chemical Immunology, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. m.verdoes1@lumc.nl., Scheeren FA; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Jul; Vol. 9 (7), pp. 1101-1116. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-024-01342-z