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Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.

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Title: Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.
Authors: El Hebieshy AF; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl.; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl., Wijfjes Z; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Institute for Chemical Immunology, Nijmegen, the Netherlands., Le Gall CM; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Middelburg J; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., de Roode KE; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Tagworks Pharmaceuticals, Nijmegen, the Netherlands., Fennemann FL; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Sluijter M; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., van Hall T; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Dijkstra DJ; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., van Dalen FJ; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Rodgers Furones A; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., van der Schoot JMS; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Derksen I; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., de Haard H; Argenx BV, Gent, Belgium., van der Woning B; Argenx BV, Gent, Belgium., Talavera Ormeño CMP; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., van Doodewaerd BR; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Figdor CG; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., van der Heden van Noort GJ; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Parren PWHI; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands., Heskamp S; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Ovaa H; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Verdoes M; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Institute for Chemical Immunology, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. m.verdoes1@lumc.nl., Scheeren FA; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Jul; Vol. 9 (7), pp. 1101-1116. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.
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  Data: <searchLink fieldCode="AU" term="%22El+Hebieshy+AF%22">El Hebieshy AF</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl.; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Wijfjes+Z%22">Wijfjes Z</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Institute for Chemical Immunology, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Le+Gall+CM%22">Le Gall CM</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Middelburg+J%22">Middelburg J</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Roode+KE%22">de Roode KE</searchLink>; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Tagworks Pharmaceuticals, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fennemann+FL%22">Fennemann FL</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sluijter+M%22">Sluijter M</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hall+T%22">van Hall T</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dijkstra+DJ%22">Dijkstra DJ</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Trouw+LA%22">Trouw LA</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dalen+FJ%22">van Dalen FJ</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rodgers+Furones+A%22">Rodgers Furones A</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Schoot+JMS%22">van der Schoot JMS</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Derksen+I%22">Derksen I</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Haard+H%22">de Haard H</searchLink>; Argenx BV, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22van+der+Woning+B%22">van der Woning B</searchLink>; Argenx BV, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Talavera+Ormeño+CMP%22">Talavera Ormeño CMP</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Doodewaerd+BR%22">van Doodewaerd BR</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Figdor+CG%22">Figdor CG</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Heden+van+Noort+GJ%22">van der Heden van Noort GJ</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Parren+PWHI%22">Parren PWHI</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Heskamp+S%22">Heskamp S</searchLink>; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ovaa+H%22">Ovaa H</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verdoes+M%22">Verdoes M</searchLink>; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Institute for Chemical Immunology, Nijmegen, the Netherlands. m.verdoes1@lumc.nl.; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. m.verdoes1@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Scheeren+FA%22">Scheeren FA</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Jul; Vol. 9 (7), pp. 1101-1116. <i>Date of Electronic Publication: </i>2025 Apr 09.
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