ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility.
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| Title: | ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility. |
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| Authors: | Kohnken R; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Fossey S; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Buck WR; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Segreti J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Treadway J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Green J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Koshman YE; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Zafiratos M; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Mittelstadt S; Preclinical Safety, AbbVie Inc., North Chicago, IL 60064, United States., Blomme E; Development Biologic Sciences, AbbVie Inc., North Chicago, IL 60064, United States., Foley CM; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States. |
| Source: | Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 May 01; Vol. 205 (1), pp. 233-244. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1096-0929 |
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| DOI: | 10.1093/toxsci/kfaf021 |
