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ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility.

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Title: ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility.
Authors: Kohnken R; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Fossey S; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Buck WR; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Segreti J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Treadway J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Green J; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Koshman YE; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States., Zafiratos M; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States., Mittelstadt S; Preclinical Safety, AbbVie Inc., North Chicago, IL 60064, United States., Blomme E; Development Biologic Sciences, AbbVie Inc., North Chicago, IL 60064, United States., Foley CM; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 May 01; Vol. 205 (1), pp. 233-244.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility.
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  Data: <searchLink fieldCode="AU" term="%22Kohnken+R%22">Kohnken R</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Fossey+S%22">Fossey S</searchLink>; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Buck+WR%22">Buck WR</searchLink>; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Segreti+J%22">Segreti J</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Treadway+J%22">Treadway J</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Green+J%22">Green J</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Koshman+YE%22">Koshman YE</searchLink>; Investigative Toxicology and Pathology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Zafiratos+M%22">Zafiratos M</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Mittelstadt+S%22">Mittelstadt S</searchLink>; Preclinical Safety, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Blomme+E%22">Blomme E</searchLink>; Development Biologic Sciences, AbbVie Inc., North Chicago, IL 60064, United States.<br /><searchLink fieldCode="AU" term="%22Foley+CM%22">Foley CM</searchLink>; Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, United States.
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  Data: <searchLink fieldCode="JN" term="%229805461%22">Toxicological sciences : an official journal of the Society of Toxicology</searchLink> [Toxicol Sci] 2025 May 01; Vol. 205 (1), pp. 233-244.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9805461 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0929 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210960929%22">10960929 </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1093/toxsci/kfaf021
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        Text: English
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              Text: 2025 May 01
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