Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.

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Title: Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.
Authors: Muñoz Sandoval D; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.; Instituto de Microbiologia, Universidad San Francisco de Quito , Quito, Ecuador., Bach FA; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Ivens A; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Harding AC; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Smith NL; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Mazurczyk M; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Themistocleous Y; The Jenner Institute, University of Oxford , Oxford, UK., Edwards NJ; The Jenner Institute, University of Oxford , Oxford, UK., Silk SE; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Barrett JR; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Cowan GJM; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Napolitani G; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Savill NJ; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Draper SJ; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK., Minassian AM; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK., Nahrendorf W; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Spence PJ; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.
Source: The Journal of experimental medicine [J Exp Med] 2025 Jul 07; Vol. 222 (7). Date of Electronic Publication: 2025 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1540-9538
DOI:10.1084/jem.20241667