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Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.

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Title: Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.
Authors: Muñoz Sandoval D; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.; Instituto de Microbiologia, Universidad San Francisco de Quito , Quito, Ecuador., Bach FA; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Ivens A; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Harding AC; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Smith NL; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Mazurczyk M; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Themistocleous Y; The Jenner Institute, University of Oxford , Oxford, UK., Edwards NJ; The Jenner Institute, University of Oxford , Oxford, UK., Silk SE; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Barrett JR; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Cowan GJM; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Napolitani G; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK., Savill NJ; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Draper SJ; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK., Minassian AM; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK., Nahrendorf W; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK., Spence PJ; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.
Source: The Journal of experimental medicine [J Exp Med] 2025 Jul 07; Vol. 222 (7). Date of Electronic Publication: 2025 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.
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  Data: <searchLink fieldCode="AU" term="%22Muñoz+Sandoval+D%22">Muñoz Sandoval D</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.; Instituto de Microbiologia, Universidad San Francisco de Quito , Quito, Ecuador.<br /><searchLink fieldCode="AU" term="%22Bach+FA%22">Bach FA</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Ivens+A%22">Ivens A</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Harding+AC%22">Harding AC</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Smith+NL%22">Smith NL</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Mazurczyk+M%22">Mazurczyk M</searchLink>; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Themistocleous+Y%22">Themistocleous Y</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+NJ%22">Edwards NJ</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silk+SE%22">Silk SE</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Barrett+JR%22">Barrett JR</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cowan+GJM%22">Cowan GJM</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Napolitani+G%22">Napolitani G</searchLink>; Weatherall Institute of Molecular Medicine, University of Oxford , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Savill+NJ%22">Savill NJ</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Draper+SJ%22">Draper SJ</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Minassian+AM%22">Minassian AM</searchLink>; The Jenner Institute, University of Oxford , Oxford, UK.; Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre , Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Nahrendorf+W%22">Nahrendorf W</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spence+PJ%22">Spence PJ</searchLink>; Institute of Immunology and Infection Research, University of Edinburgh , Edinburgh, UK.
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              Text: 2025 Jul 07
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