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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.

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Title: Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.
Authors: Capello M; Genmab BV, Utrecht, Netherlands., Sette A; Genmab BV, Utrecht, Netherlands., Plantinga T; Genmab BV, Utrecht, Netherlands., Thalhauser CJ; Genmab US, Plainsboro, New Jersey, USA., Spires VM; Genmab US, Plainsboro, New Jersey, USA., Nürmberger KB; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Blum JM; Genmab US, Plainsboro, New Jersey, USA., Higgs BW; Genmab US, Plainsboro, New Jersey, USA., Garrido Castro P; Genmab BV, Utrecht, Netherlands., Yu C; Genmab US, Plainsboro, New Jersey, USA., Costa Sa C; Genmab US, Plainsboro, New Jersey, USA., Fellermeier-Kopf S; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Burm SM; Genmab BV, Utrecht, Netherlands., Strumane K; Genmab BV, Utrecht, Netherlands., Toker A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Imle A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., de Andrade Pereira B; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Muik A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Ahmadi T; Genmab US, Plainsboro, New Jersey, USA., Türeci Ö; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Fereshteh M; Genmab US, Plainsboro, New Jersey, USA., Sahin U; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Jure-Kunkel M; Genmab US, Plainsboro, New Jersey, USA npe@genmab.com mjk@genmab.com., Pencheva N; Genmab BV, Utrecht, Netherlands npe@genmab.com mjk@genmab.com.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Apr 10; Vol. 13 (4). Date of Electronic Publication: 2025 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2024-011377