Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field.

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Title: Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field.
Authors: Lumley SF; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Infectious Diseases and Microbiology, Oxford University Hospitals, Oxford, UK., Mokaya J; Parasites and Microbes, Wellcome Sanger Institute, Cambridge, UK., Maponga TG; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; National Health Laboratory Service, Tygerberg Business Unit, Cape Town, South Africa., Kramvis A; Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa., Dusheiko G; University of the Witwatersrand, Johannesburg, South Africa; Institute of Liver Studies, King's College Hospital, London, UK., Irving W; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK., Delphin M; The Francis Crick Institute, London, UK., Said Mohammed K; The Francis Crick Institute, London, UK., Downs LO; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Infectious Diseases and Microbiology, Oxford University Hospitals, Oxford, UK; Kenya Medical Research Institute Wellcome Trust, Kilifi, Kenya., Waddilove E; The Francis Crick Institute, London, UK., Anderson M; The Francis Crick Institute, London, UK; Africa Health Research Institute, Durban, South Africa; Botswana Harvard Health Partnership, Gaborone, Botswana., Iwuji C; Africa Health Research Institute, Durban, South Africa; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Msomi N; Discipline of Virology, University of KwaZulu-Natal and National Health Laboratory Service, Durban, South Africa., Ocama P; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda., Hamid S; Department of Medicine, Aga Khan University, Karachi, Pakistan., Adda D; World Hepatitis Alliance, Geneva, Switzerland; Center for Initiative and Development and Chagro-Care Trust, Jalingo, Nigeria., Halford R; World Hepatitis Alliance, Geneva, Switzerland., Kabagambe K; The National Organisation for People Living with Hepatitis B, Kampala, Uganda., Benschop KSM; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Inzaule S; Amsterdam Institute for Global Health and Development and Department of Global Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Chan P; Department of Communicable Diseases, WHO South-East Asia Regional Office, New Delhi, India., Paul MAS; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland., Izumi K; Division of Programmes for Disease Control, WHO Western Pacific Regional Office, Manila, Philippines., Nisa T; Division of Programmes for Disease Control, WHO Western Pacific Regional Office, Manila, Philippines., De Dieu Iragena J; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland., Girón-Callejas A; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland., Kpossou AR; University of Abomey-Calavi, Abomey-Calavi, Benin., Jamiyu G; National AIDS, Viral Hepatitis and STIs Control Programme, Abuja, Nigeria., Emmanuel O; National AIDS, Viral Hepatitis and STIs Control Programme, Abuja, Nigeria., Balkissa M; Programme National de Lutte contre le Sida et les Hépatites (PNLSH), Ministère de la Santé Publique, de la Population et des Affaires Sociales, Niamey, Niger., Keita M; The Sectoral Unit for the Fight against HIV, Tuberculosis and Viral Hepatitis, Ministry of Health, Bamako, Mali., Prabdial-Sing N; National Institute for Communicable Diseases and National Health Laboratory Service and the Faculty of Health Sciences, Witwatersrand University, Johannesburg, South Africa; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa., Martinez A; Gorgas Memorial Institute for Health Studies, Panama City, Panama; Department of Microbiology and Immunology, University of Panama, Panama City, Panama., Magongo EN; Ministry of Health, STD/AIDS Control Program, Kampala, Uganda., Shao Y; National Centre for AIDS/STD Control and Prevention A, Chinese Center for Disease Control and Prevention, Changping Laboratory, Beijing, China., Sued O; HIV, STI, Viral Hepatitis and TB Unit, Department of Communicable Disease Prevention, Control, and Elimination, Pan American Health Organization, Washington, DC, USA., Sereno LS; HIV, STI, Viral Hepatitis and TB Unit, Department of Communicable Disease Prevention, Control, and Elimination, Pan American Health Organization, Washington, DC, USA., Shafer RW; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA., Lesi O; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland; University of Lagos, Lagos, Nigeria., Faini D; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland., Easterbrook P; Department of Global HIV, Hepatitis and Sexually Transmitted Infections, WHO, Geneva, Switzerland., Duncombe C; International Association of Providers of AIDS Care, Washington DC, USA., Jordan MR; Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA; Collaboratory for Emerging Infectious Diseases and Response, Tufts University, Medford, MA, USA., Matthews PC; Kenya Medical Research Institute Wellcome Trust, Kilifi, Kenya; Division of Infection and Immunity, University College London, London, UK; Department of Infectious Diseases, University College London Hospital, London, UK. Electronic address: philippa.matthews@crick.ac.uk.
Source: The Lancet. Microbe [Lancet Microbe] 2025 Aug; Vol. 6 (8), pp. 101076. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-5247
DOI:10.1016/j.lanmic.2025.101076