Molecular hyperselection for optimal choice of first-line targeted therapy independent of primary tumor sidedness: An exploratory analysis of the randomized FIRE-3 study performed in RAS wild-type metastatic colorectal cancer.

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Title: Molecular hyperselection for optimal choice of first-line targeted therapy independent of primary tumor sidedness: An exploratory analysis of the randomized FIRE-3 study performed in RAS wild-type metastatic colorectal cancer.
Authors: Weiss L; Department of Medicine III, LMU Klinikum, University of Munich, Munich, Germany. Electronic address: Lena.Weiss@med.uni-muenchen.de., Stintzing S; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Stahler A; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Benedikt Westphalen C; Department of Medicine III, LMU Klinikum, University of Munich, Munich, Germany; Comprehensive Cancer Center Munich, LMU Klinikum, University of Munich, Munich, Germany., von Weikersthal LF; Praxis für Hämatologie/Onkologie, MVZ St. Marien, Amberg, Germany., Decker T; Oncological Practice, Ravensburg, Germany., Kiani A; Department of Hematology and Oncology, Klinikum Bayreuth GmbH, Bayreuth, Germany and Comprehensive Cancer Center-EMN, Erlangen, Germany., Vehling-Kaiser U; Oncological Practice, Landshut, Germany., Al-Batran SE; Institute of Clinical Cancer Research at Krankenhaus Nordwest University Cancer Center, Frankfurt, Germany., Heintges T; Department of Medicine II, Rheinlandklinikum Neuss, Neuss, Germany., Lerchenmüller CA; Oncological Practice, Münster, Germany., Kahl C; Department of Haematology and Oncology, Städtisches Klinikum Magdeburg, Magdeburg, Germany; Department of Haematology, Oncology and Palliative Care, Klinikum Magdeburg gGmbH, Magdeburg, Germany; Department of Hematology, Oncology, and Palliative Care, University of Rostock, Rostock, Germany., Seipelt G; Department of Hematology, Oncology, and Palliative Care, University of Rostock, Rostock, Germany; Oncological Practice, Bad Soden, Germany., Kullmann F; Oncological Practice, Bad Soden, Germany; Department of Medicine I, Klinikum Weiden, Weiden, Germany., Heinrich K; Department of Medicine III, LMU Klinikum, University of Munich, Munich, Germany., Holch JW; Department of Medicine III, LMU Klinikum, University of Munich, Munich, Germany., Alig A; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Jung A; Department of Medicine I, Klinikum Weiden, Weiden, Germany; Institute of Pathology, University of Munich, Munich, Germany., Modest DP; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Heinemann V; Department of Medicine III, LMU Klinikum, University of Munich, Munich, Germany; Comprehensive Cancer Center Munich, LMU Klinikum, University of Munich, Munich, Germany.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 May 15; Vol. 221, pp. 115399. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0852
DOI:10.1016/j.ejca.2025.115399