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Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation.

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Title: Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation.
Authors: Mujtaba MA; Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.; Center for Health Research, Northern Border University, Arar, Saudi Arabia., Rashid MA; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Godbole MD; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India., Alhamhoom Y; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Shende DS; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India., Alshehri S; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia., Akbar MJ; Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Kaleem M; Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India., Mahajan UN; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India., Shahzad N; Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 Mar 28; Vol. 16, pp. 1577331. Date of Electronic Publication: 2025 Mar 28 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation.
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  Data: <searchLink fieldCode="AU" term="%22Mujtaba+MA%22">Mujtaba MA</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.; Center for Health Research, Northern Border University, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Rashid+MA%22">Rashid MA</searchLink>; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Godbole+MD%22">Godbole MD</searchLink>; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Alhamhoom+Y%22">Alhamhoom Y</searchLink>; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Shende+DS%22">Shende DS</searchLink>; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Alshehri+S%22">Alshehri S</searchLink>; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Akbar+MJ%22">Akbar MJ</searchLink>; Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kaleem+M%22">Kaleem M</searchLink>; Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Mahajan+UN%22">Mahajan UN</searchLink>; Department of Pharmaceutical Analysis, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Shahzad+N%22">Shahzad N</searchLink>; Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
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