A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats.

Saved in:
Bibliographic Details
Title: A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats.
Authors: Niessen J; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Arendt N; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Sjöblom M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Dubbelboer IR; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Borchardt T; Product Development Science & Technology, AbbVie Inc., North Chicago, IL, United States., Koziolek M; Small Molecule CMC Development, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany., Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden., Lennernäs H; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Indulkar A; Small Molecule CMC Development, Research & Development, AbbVie Inc., North Chicago, IL, United States., Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden. Electronic address: david.dahlgren@uu.se.
Source: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2025 Jun; Vol. 211, pp. 114719. Date of Electronic Publication: 2025 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-3441
DOI:10.1016/j.ejpb.2025.114719