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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats.

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Title: A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats.
Authors: Niessen J; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Arendt N; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Sjöblom M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Dubbelboer IR; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Borchardt T; Product Development Science & Technology, AbbVie Inc., North Chicago, IL, United States., Koziolek M; Small Molecule CMC Development, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany., Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden., Lennernäs H; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Indulkar A; Small Molecule CMC Development, Research & Development, AbbVie Inc., North Chicago, IL, United States., Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden. Electronic address: david.dahlgren@uu.se.
Source: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2025 Jun; Vol. 211, pp. 114719. Date of Electronic Publication: 2025 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats.
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  Data: <searchLink fieldCode="AU" term="%22Niessen+J%22">Niessen J</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Arendt+N%22">Arendt N</searchLink>; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Sjöblom+M%22">Sjöblom M</searchLink>; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Dubbelboer+IR%22">Dubbelboer IR</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Borchardt+T%22">Borchardt T</searchLink>; Product Development Science & Technology, AbbVie Inc., North Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Koziolek+M%22">Koziolek M</searchLink>; Small Molecule CMC Development, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22Hedeland+M%22">Hedeland M</searchLink>; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lennernäs+H%22">Lennernäs H</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Indulkar+A%22">Indulkar A</searchLink>; Small Molecule CMC Development, Research & Development, AbbVie Inc., North Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Dahlgren+D%22">Dahlgren D</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden. Electronic address: david.dahlgren@uu.se.
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  Data: <searchLink fieldCode="JN" term="%229109778%22">European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V</searchLink> [Eur J Pharm Biopharm] 2025 Jun; Vol. 211, pp. 114719. <i>Date of Electronic Publication: </i>2025 Apr 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9109778 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3441 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209396411%22">09396411 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharm Biopharm <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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