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Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): update to study protocol and addition of a statistical analysis plan and health economic analysis plan for a randomised controlled surgical trial.

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Title: Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): update to study protocol and addition of a statistical analysis plan and health economic analysis plan for a randomised controlled surgical trial.
Authors: Lee CN; Department of Ophthalmology, King's College Hospital, London, UK., Desai R; Department of Ophthalmology, King's College Hospital, London, UK., Ramazzotto L; Faculty of Life Sciences and Medicine, King's College London, London, UK., Wafa H; Population Health Sciences, Faculty and Life Science and Medicine, King's College London, London, UK., Wang Y; Population Health Sciences, Faculty and Life Science and Medicine, King's College London, London, UK., Bunce C; The London School of Hygiene and Tropical Medicine, London, UK., Doungsong K; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales., Ezeofor V; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales., Edwards RT; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales., Lois N; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, Northern Ireland., Steel DH; Bioscience Institute, Newcastle University, Newcastle, UK., Peto T; Network of Ophthalmic Reading Centres UK, Queen's University, Belfast, Northern Ireland., Hillenkamp J; Eye Clinic, University of Wurzburg, Wurzburg, Germany., van Meurs JC; Rotterdam Eye Hospital and Erasmus Medical Centre, Rotterdam, the Netherlands., Reeves BC; University of Bristol, Bristol, UK., Jackson TL; Faculty of Life Sciences and Medicine, King's College London, London, UK. t.jackson1@nhs.net.
Source: Trials [Trials] 2025 Apr 14; Vol. 26 (1), pp. 131. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): update to study protocol and addition of a statistical analysis plan and health economic analysis plan for a randomised controlled surgical trial.
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  Data: <searchLink fieldCode="AU" term="%22Lee+CN%22">Lee CN</searchLink>; Department of Ophthalmology, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Desai+R%22">Desai R</searchLink>; Department of Ophthalmology, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Ramazzotto+L%22">Ramazzotto L</searchLink>; Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wafa+H%22">Wafa H</searchLink>; Population Health Sciences, Faculty and Life Science and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Population Health Sciences, Faculty and Life Science and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bunce+C%22">Bunce C</searchLink>; The London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Doungsong+K%22">Doungsong K</searchLink>; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales.<br /><searchLink fieldCode="AU" term="%22Ezeofor+V%22">Ezeofor V</searchLink>; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales.<br /><searchLink fieldCode="AU" term="%22Edwards+RT%22">Edwards RT</searchLink>; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales.<br /><searchLink fieldCode="AU" term="%22Lois+N%22">Lois N</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Steel+DH%22">Steel DH</searchLink>; Bioscience Institute, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Peto+T%22">Peto T</searchLink>; Network of Ophthalmic Reading Centres UK, Queen's University, Belfast, Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Hillenkamp+J%22">Hillenkamp J</searchLink>; Eye Clinic, University of Wurzburg, Wurzburg, Germany.<br /><searchLink fieldCode="AU" term="%22van+Meurs+JC%22">van Meurs JC</searchLink>; Rotterdam Eye Hospital and Erasmus Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Reeves+BC%22">Reeves BC</searchLink>; University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+TL%22">Jackson TL</searchLink>; Faculty of Life Sciences and Medicine, King's College London, London, UK. t.jackson1@nhs.net.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2025 Apr 14; Vol. 26 (1), pp. 131. <i>Date of Electronic Publication: </i>2025 Apr 14.
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