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Post-cleavage target residence determines asymmetry in non-homologous end joining of Cas12a-induced DNA double strand breaks.

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Title: Post-cleavage target residence determines asymmetry in non-homologous end joining of Cas12a-induced DNA double strand breaks.
Authors: Chen RD; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Hangzhou Qiantang Hospital, Hangzhou, Zhejiang, 310018, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Yang Y; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Liu KM; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Hu JZ; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Feng YL; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Hangzhou Qiantang Hospital, Hangzhou, Zhejiang, 310018, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Yang CY; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Jiang RR; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China.; Zhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang, 314006, People's Republic of China., Liu SC; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Hangzhou Qiantang Hospital, Hangzhou, Zhejiang, 310018, People's Republic of China., Wang Y; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China., Han PA; Institute of Animal Husbandry and Inner Mongolia Key Laboratory of Sugarbeet Genetics and Germplasm Enhancement, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot, Inner Mongolia, 010031, People's Republic of China., Tian RG; Institute of Animal Husbandry and Inner Mongolia Key Laboratory of Sugarbeet Genetics and Germplasm Enhancement, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot, Inner Mongolia, 010031, People's Republic of China., Wang YL; Zhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang, 314006, People's Republic of China., Xu SM; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China. shimingxu@zju.edu.cn.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China. shimingxu@zju.edu.cn., Xie AY; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People's Republic of China. anyongxie@zju.edu.cn.; Hangzhou Qiantang Hospital, Hangzhou, Zhejiang, 310018, People's Republic of China. anyongxie@zju.edu.cn.; Institute of Translational Medicine, Zhejiang University School of Medicine, and Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310029, People's Republic of China. anyongxie@zju.edu.cn.
Source: Genome biology [Genome Biol] 2025 Apr 14; Vol. 26 (1), pp. 96. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1474-760X
DOI:10.1186/s13059-025-03567-w