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Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.

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Title: Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.
Authors: Gozdecka M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. mg717@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. mg717@cam.ac.uk., Dudek M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Wen S; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK., Gu M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Stopforth RJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Rak J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Damaskou A; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Grice GL; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., McLoughlin MA; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Bond L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Wilson R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Giotopoulos G; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Shanmugiah VM; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Bakar RB; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Yankova E; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Cooper JL; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Narayan N; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Horton SJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Asby R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Pask DC; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Mupo A; Altos Labs, Granta Park, Cambridge, UK., Duddy G; The Francis Crick Institute, London, UK., Marando L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Georgomanolis T; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University Hospital Cologne, Cologne, Germany., Carter P; Section of Cardiovascular Medicine, The Victor Phillip Dahdalleh Heart and Lung Research Institute, The University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK., Ramesh AP; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Dunn WG; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Barcena C; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain., Gallipoli P; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Yusa K; Stem Cell Genetics, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK., Wright P; Department of Anatomic Pathology, Canterbury Health Laboratories, Christchurch, New Zealand., Quiros PM; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain., Frezza C; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University Hospital Cologne, Cologne, Germany.; Institute of Genetics, Faculty of Mathematics and Natural Sciences, Faculty of Medicine, University of Cologne, Cologne, Germany., Nathan JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Kaser A; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Kar S; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Tzelepis K; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK., Fabre MA; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Huntly BJP; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. bjph2@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. bjph2@cam.ac.uk., Vassiliou GS; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. gsv20@cam.ac.uk.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. gsv20@cam.ac.uk.
Source: Nature [Nature] 2025 Jun; Vol. 642 (8067), pp. 431-441. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.
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  Data: <searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. mg717@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. mg717@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wen+S%22">Wen S</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gu+M%22">Gu M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stopforth+RJ%22">Stopforth RJ</searchLink>; 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Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. bjph2@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. gsv20@cam.ac.uk.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. gsv20@cam.ac.uk.
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