Perspectives on cancer therapy-synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges.

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Title: Perspectives on cancer therapy-synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges.
Authors: Peng S; Department of Oncology, Graduate Collaborative Training Base of The First People's Hospital of Xiangtan City, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.; Department of Oncology, The First People's Hospital of Xiangtan City, Xiangtan, Hunan, 411101, China., Long M; Department of Oncology, Graduate Collaborative Training Base of The First People's Hospital of Xiangtan City, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.; Department of Oncology, The First People's Hospital of Xiangtan City, Xiangtan, Hunan, 411101, China., Chen Q; Department of Anesthesiology, The First People's Hospital of Chenzhou, The Chenzhou Affiliated Hospital, Hengyang Medical School, University of South China, Chenzhou, Hunan, 423000, China., Yin Z; Department of Oncology, Graduate Collaborative Training Base of The First People's Hospital of Xiangtan City, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.; Department of Oncology, The First People's Hospital of Xiangtan City, Xiangtan, Hunan, 411101, China., Zeng C; Department of Pathology, Yueyang Central Hospital, Yueyang, China., Zhang W; Department of Pathology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, 437100, Hubei, China., Wen Q; Department of Oncology, Graduate Collaborative Training Base of The First People's Hospital of Xiangtan City, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.; Department of Oncology, The First People's Hospital of Xiangtan City, Xiangtan, Hunan, 411101, China., Zhang X; Department of Oncology, Graduate Collaborative Training Base of The First People's Hospital of Xiangtan City, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.; Department of Oncology, The First People's Hospital of Xiangtan City, Xiangtan, Hunan, 411101, China., Ke W; Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China. wqke2@stu.edu.cn., Wu Y; Department of Pathology, Xiangtan Center Hospital, Xiangtan City, Hunan province, 411100, China. 1345270430@qq.com.; Department of Pathology, The Affiliated Hospital of Hunan University, Xiangtan City, Hunan Province, China. 1345270430@qq.com.
Source: Cell death discovery [Cell Death Discov] 2025 Apr 16; Vol. 11 (1), pp. 179. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-7716
DOI:10.1038/s41420-025-02418-8