Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease.

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Title: Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease.
Authors: Mengel D; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Otfried-Müller-Straße 27, 72076, Tübingen, Germany., Soter E; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Ott JM; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Wacker M; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Leyva A; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Psychiatry and Psychotherapy, Charitéplatz 1, 10117, Berlin, Germany., Hellmann-Regen J; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Neurosciences, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Center for Mental Health (DZPG), partner site Berlin, Charitéplatz 1, 10117, Berlin, Germany., Schneider LS; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Psychiatry and Psychotherapy, Charitéplatz 1, 10117, Berlin, Germany.; German Center for Mental Health (DZPG), partner site Berlin, Charitéplatz 1, 10117, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Experimental and Clinical Research Center (ECRC), Lindenberger Weg 80, 13125, Berlin, Germany., Wang X; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Neurosciences, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Center for Mental Health (DZPG), partner site Berlin, Charitéplatz 1, 10117, Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.; School of Medicine, Technical University of Munich, Department of Psychiatry and Psychotherapy, Ismaninger Str. 22, 81675, Munich, Germany.; University of Edinburgh and UK Dementia Research Institute (UK DRI), Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK., Spruth E; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany., Altenstein S; German Center for Neurodegenerative Diseases (DZNE), Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3a, 37075, Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Von-Siebold-Straße 3a, 37075, Göttingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal., Hansen N; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Von-Siebold-Straße 3a, 37075, Göttingen, Germany., Rostamzadeh A; Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany., Incesoy EI; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, University Clinic Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Janowitz D; German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Ewers M; German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU, Nussbaumstraße 7, 80336, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK., Rauchmann B; Department of Psychiatry and Psychotherapy, University Hospital, LMU, Nussbaumstraße 7, 80336, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Department of Neuroradiology, University Hospital LMU, Marchioninistraße 15, 81377, Munich, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Straße 20, 18147, Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Straße 20, 18147, Rostock, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Straße 20, 18147, Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Straße 20, 18147, Rostock, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Otfried-Müller-Straße 27, 72076, Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Sodenkamp S; German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Otfried-Müller-Straße 27, 72076, Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstraße 14, 72076, Tübingen, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Brustkern J; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Stark M; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Shao K; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department of Neurology, XuanWu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China., Lüsebrink F; German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Straße 20, 18147, Rostock, Germany., Yakupov R; German Center for Neurodegenerative Diseases (DZNE), Gehlsheimer Straße 20, 18147, Rostock, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Institute for Medical Biometry, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany., Hetzer S; Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Philippstraße 13, 10115, Berlin, Germany., Dechent P; MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University Göttingen, Von-Siebold-Straße 3a, 37075, Göttingen, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany., Berron D; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sölvegatan 17, 223 62, Lund, Sweden., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Straße 27, 53127, Bonn, Germany.; Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany., Synofzik M; Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany. matthis.synofzik@uni-tuebingen.de.; German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Otfried-Müller-Straße 27, 72076, Tübingen, Germany. matthis.synofzik@uni-tuebingen.de.
Corporate Authors: DELCODE study group
Source: Molecular psychiatry [Mol Psychiatry] 2025 Jul; Vol. 30 (7), pp. 3150-3159. Date of Electronic Publication: 2025 Apr 18.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03021-0