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CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.

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Title: CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.
Authors: Kwiatkowski N; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Liang T; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Sha Z; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Collier PN; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Yang A; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Sathappa M; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Paul A; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Su L; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Zheng X; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Aversa R; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Li K; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Mehovic R; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Kolodzy C; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Breitkopf SB; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Chen D; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Howarth CL; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Yuan K; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Jo H; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Growney JD; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Weiss M; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA., Williams J; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA. Electronic address: jwilliams@kymeratx.com.
Source: Cell chemical biology [Cell Chem Biol] 2025 Apr 17; Vol. 32 (4), pp. 556-569.e24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.
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  Data: <searchLink fieldCode="AU" term="%22Kwiatkowski+N%22">Kwiatkowski N</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Liang+T%22">Liang T</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Sha+Z%22">Sha Z</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Collier+PN%22">Collier PN</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Yang+A%22">Yang A</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Sathappa+M%22">Sathappa M</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Paul+A%22">Paul A</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Su+L%22">Su L</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Aversa+R%22">Aversa R</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Mehovic+R%22">Mehovic R</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Kolodzy+C%22">Kolodzy C</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Breitkopf+SB%22">Breitkopf SB</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Howarth+CL%22">Howarth CL</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+K%22">Yuan K</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Jo+H%22">Jo H</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Growney+JD%22">Growney JD</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+M%22">Weiss M</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Williams+J%22">Williams J</searchLink>; Kymera Therapeutics, Inc., Biological Sciences, 500 North Beacon St. 4th Floor, Watertown, MA 02472, USA. Electronic address: jwilliams@kymeratx.com.
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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2025 Apr 17; Vol. 32 (4), pp. 556-569.e24.
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