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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.

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Title: Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.
Authors: Matuskova H; SOTIO Biotech a.s, Prague, Czech Republic., Marasek P; SOTIO Biotech a.s, Prague, Czech Republic., Mazhara V; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Simonova E; SOTIO Biotech a.s, Prague, Czech Republic., Kosinova L; SOTIO Biotech a.s, Prague, Czech Republic., Danek P; SOTIO Biotech a.s, Prague, Czech Republic., Danova K; SOTIO Biotech a.s, Prague, Czech Republic., Sajnerova K; SOTIO Biotech a.s, Prague, Czech Republic., Malatova I; SOTIO Biotech a.s, Prague, Czech Republic., Hrabankova K; SOTIO Biotech a.s, Prague, Czech Republic., Greco D; SOTIO Biotech a.s, Prague, Czech Republic., Martinec O; SOTIO Biotech a.s, Prague, Czech Republic., Fabisik M; SOTIO Biotech a.s, Prague, Czech Republic., Podzimkova N; SOTIO Biotech a.s, Prague, Czech Republic., Hladikova K; SOTIO Biotech a.s, Prague, Czech Republic., Behalova K; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Antosova Z; SOTIO Biotech a.s, Prague, Czech Republic., Sirova M; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Mikyskova R; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic., Reinis M; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic., Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Béchard D; Cytune Pharma S.A.S, Nantes, France., Moebius U; SOTIO Biotech a.s, Prague, Czech Republic., Palova Jelinkova L; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic., Spisek R; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic., Steegmaier M; SOTIO Biotech a.s, Prague, Czech Republic., Adkins I; SOTIO Biotech a.s, Prague, Czech Republic adkins@sotio.com.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Apr 17; Vol. 13 (4). Date of Electronic Publication: 2025 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2024-010736