Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.
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| Title: | Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons. |
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| Authors: | Worf K; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Matosin N; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia., Gerstner N; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Fröhlich AS; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Koller AC; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Thiele H; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University Medical Center Mannheim/University of Heidelberg, Mannheim, Germany., Udawela M; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Scarr E; The Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia., Dean B; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; The Department of Florey, The University of Melbourne, Parkville, VIC, Australia., Theis FJ; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany., Mueller NS; Institute of Computational Biology, Helmholtz Center, Munich, Germany., Knauer-Arloth J; Institute of Computational Biology, Helmholtz Center, Munich, Germany. arloth@psych.mpg.de.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany. arloth@psych.mpg.de. |
| Source: | Translational psychiatry [Transl Psychiatry] 2025 Apr 19; Vol. 15 (1), pp. 153. Date of Electronic Publication: 2025 Apr 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2158-3188 |
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| DOI: | 10.1038/s41398-025-03366-8 |
