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Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.

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Title: Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.
Authors: Worf K; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Matosin N; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia., Gerstner N; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Fröhlich AS; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Koller AC; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Thiele H; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University Medical Center Mannheim/University of Heidelberg, Mannheim, Germany., Udawela M; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Scarr E; The Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia., Dean B; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; The Department of Florey, The University of Melbourne, Parkville, VIC, Australia., Theis FJ; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany., Mueller NS; Institute of Computational Biology, Helmholtz Center, Munich, Germany., Knauer-Arloth J; Institute of Computational Biology, Helmholtz Center, Munich, Germany. arloth@psych.mpg.de.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany. arloth@psych.mpg.de.
Source: Translational psychiatry [Transl Psychiatry] 2025 Apr 19; Vol. 15 (1), pp. 153. Date of Electronic Publication: 2025 Apr 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Worf+K%22">Worf K</searchLink>; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Matosin+N%22">Matosin N</searchLink>; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gerstner+N%22">Gerstner N</searchLink>; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhlich+AS%22">Fröhlich AS</searchLink>; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Koller+AC%22">Koller AC</searchLink>; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Degenhardt+F%22">Degenhardt F</searchLink>; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Thiele+H%22">Thiele H</searchLink>; Cologne Center for Genomics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rietschel+M%22">Rietschel M</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University Medical Center Mannheim/University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Udawela+M%22">Udawela M</searchLink>; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Scarr+E%22">Scarr E</searchLink>; The Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dean+B%22">Dean B</searchLink>; The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; The Department of Florey, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Theis+FJ%22">Theis FJ</searchLink>; Institute of Computational Biology, Helmholtz Center, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+NS%22">Mueller NS</searchLink>; Institute of Computational Biology, Helmholtz Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Knauer-Arloth+J%22">Knauer-Arloth J</searchLink>; Institute of Computational Biology, Helmholtz Center, Munich, Germany. arloth@psych.mpg.de.; Department of Gene and Environment, Max Planck Institute of Psychiatry, Munich, Germany. arloth@psych.mpg.de.
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