Enhanced CAR-T cell function and mitochondrial fitness from earlier unfractionated stem cell product in multiple myeloma.

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Title: Enhanced CAR-T cell function and mitochondrial fitness from earlier unfractionated stem cell product in multiple myeloma.
Authors: Freeman CL; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Abraham-Miranda J; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Menges M; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Atkins RM; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Noble J; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Liu H; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Corallo S; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Cuadrado Delgado LA; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Ribickas AJ; Cell Therapy Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Savid-Frontera C; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., de Avila G; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Castaneda Puglianini OA; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Ochoa-Bayona J; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Hansen DK; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Alsina M; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Baz R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Nishihori T; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Shain KH; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Locke FL; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: frederick.locke@moffitt.org.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Aug 06; Vol. 33 (8), pp. 3576-3589. Date of Electronic Publication: 2025 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2025.04.019