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Enhanced CAR-T cell function and mitochondrial fitness from earlier unfractionated stem cell product in multiple myeloma.

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Title: Enhanced CAR-T cell function and mitochondrial fitness from earlier unfractionated stem cell product in multiple myeloma.
Authors: Freeman CL; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Abraham-Miranda J; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Menges M; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Atkins RM; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Noble J; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Liu H; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Corallo S; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Cuadrado Delgado LA; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Ribickas AJ; Cell Therapy Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Savid-Frontera C; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., de Avila G; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Castaneda Puglianini OA; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Ochoa-Bayona J; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Hansen DK; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Alsina M; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Baz R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Nishihori T; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Shain KH; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Locke FL; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: frederick.locke@moffitt.org.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Aug 06; Vol. 33 (8), pp. 3576-3589. Date of Electronic Publication: 2025 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Freeman+CL%22">Freeman CL</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Abraham-Miranda+J%22">Abraham-Miranda J</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Menges+M%22">Menges M</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Atkins+RM%22">Atkins RM</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Noble+J%22">Noble J</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Corallo+S%22">Corallo S</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Cuadrado+Delgado+LA%22">Cuadrado Delgado LA</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Ribickas+AJ%22">Ribickas AJ</searchLink>; Cell Therapy Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Savid-Frontera+C%22">Savid-Frontera C</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22de+Avila+G%22">de Avila G</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Castaneda+Puglianini+OA%22">Castaneda Puglianini OA</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Ochoa-Bayona+J%22">Ochoa-Bayona J</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+DK%22">Hansen DK</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Alsina+M%22">Alsina M</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Baz+R%22">Baz R</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Nishihori+T%22">Nishihori T</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Shain+KH%22">Shain KH</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Locke+FL%22">Locke FL</searchLink>; Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: frederick.locke@moffitt.org.
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