Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed-methods study exploring participant experiences of receiving secondary findings from genomic sequencing.

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Title: Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed-methods study exploring participant experiences of receiving secondary findings from genomic sequencing.
Authors: Stafford-Smith B; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Daniel M; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Peter M; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Gurasashvili J; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Baptiste R; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Bracke-Manzanares X; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Royal Marsden NHS Foundation Trust, Fulham Road, London, United Kingdom., Georgiou L; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Green-Armytage A; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Griffin B; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Lumborg B; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Paternoster B; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Smith E; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Balasubramanian M; Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom; Division of Clinical Medicine, University of Sheffield, Sheffield, United Kingdom., Bownass L; Clinical Genetics, St Michael's Hospital Bristol, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom., Brennan P; Northern Genetics Service, Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom., Cleaver R; Peninsula Clinical Genetics Service, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Clowes V; North West Thames Regional Genetics Service, Northwick Park and St Mark's Hospital, London North West University Healthcare NHS Trust, London, United Kingdom., Costello P; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom., DeSouza B; North West Thames Regional Genetics Service, Northwick Park and St Mark's Hospital, London North West University Healthcare NHS Trust, London, United Kingdom., Dubois L; Liverpool Centre for Genomic Medicine, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom., George A; Royal Marsden NHS Foundation Trust, Fulham Road, London, United Kingdom., George E; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Harrison R; Department of Clinical Genetics, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Hawkes L; Oxford Centre for Genomic Medicine, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Humphries SE; Centre for Cardiovascular Genetics, University College London, London, United Kingdom., Jones A; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Jones EA; Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, United Kingdom; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom., Kraus A; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom., Holiday D; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom., McEntagart M; Medical Genetics, Clinical Developmental Sciences, St. George's University of London, London, United Kingdom., Somarathi S; Clinical Genetics Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom., Taylor A; East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Tripathi V; Department of Clinical Genetics, Guy's and St Thomas' Hospitals NHS Trust, London, United Kingdom., Morris S; Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Chitty LS; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Hill M; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. Electronic address: melissa.hill@ucl.ac.uk.
Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2025 Dec; Vol. 27 (12), pp. 101446. Date of Electronic Publication: 2025 Apr 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1530-0366
DOI:10.1016/j.gim.2025.101446