Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism.
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| Title: | Structure of a lasso peptide bound ET |
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| Authors: | Shihoya W; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. wtrshh9@gmail.com., Akasaka H; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan., Jordan PA; Lassogen Inc., San Diego, CA, USA., Lechner A; Lassogen Inc., San Diego, CA, USA., Okada BK; Lassogen Inc., San Diego, CA, USA., Costa Machado da Cruz G; Lassogen Inc., San Diego, CA, USA., Sano FK; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan., Tanaka T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan., Kawahara R; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan., Chaudhari R; Research Informatics, Eurofins Panlabs, Inc., Saint Charles, MO, USA., Masamune H; Lassogen Inc., San Diego, CA, USA., Burk MJ; Lassogen Inc., San Diego, CA, USA. mburk@lassogen.com., Nureki O; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp. |
| Source: | Nature communications [Nat Commun] 2025 Apr 22; Vol. 16 (1), pp. 3446. Date of Electronic Publication: 2025 Apr 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-57960-x |
