Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders.

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Title: Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders.
Authors: Solomon P; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Kaurani L; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Guiné JB; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Krüger DM; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Riquin K; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Pena T; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Burkhardt S; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Fourgeux C; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Heilbronner M; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany., Schaupp SK; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.; Centers for Psychiatry Suedwuerttemberg, Ravensburg, Ravensburg, Germany., Vogl T; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany., Arolt V; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, University of Melbourne, Melbourne, Australia.; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dietrich DE; AMEOS Clinical Center Hildesheim, Hildesheim, Germany.; Center for Systems Neuroscience Hannover, Hannover, Germany.; Department of Psychiatry, Medical School of Hannover, Hannover, Germany., Fallgatter AJ; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany.; German Center for Mental Health (DZPG), partner site Tübingen, Tübingen, Germany., Figge C; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany., Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Psychosocial Medicine, Academic Teaching Hospital Itzehoe, Itzehoe, Germany., Reininghaus EZ; Division of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Schmauß M; Clinic for Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Disease (DZNE), Göttingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Zimmermann J; Psychiatrieverbund Oldenburger Land GMBH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany., Schütz AL; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Sananbenesi F; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Sauvaget A; Nantes Université, CHU Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes, France., Falkai P; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, Munich, Germany., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Fischer A; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany., Poschmann J; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France. jeremie.poschmann@univ-nantes.fr.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Sep; Vol. 30 (9), pp. 4364-4383. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03018-9