Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial.

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Title: Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial.
Authors: Savitz J; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Figueroa-Hall LK; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Teague TK; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Yeh HW; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Zheng H; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Kuplicki R; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Burrows K; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., El-Sabbagh N; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Thomas M; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Ewers I; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Cha YH; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Guinjoan S; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Khalsa SS; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Paulus MP; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin)., Irwin MR; Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Source: The American journal of psychiatry [Am J Psychiatry] 2025 Jun 01; Vol. 182 (6), pp. 560-568. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1535-7228
DOI:10.1176/appi.ajp.20240142