The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.

Saved in:
Bibliographic Details
Title: The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.
Authors: Soni H; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Tyagi S; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Mane K; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA., Shelke AM; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA., Kumar P; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.; Public Health Research Institute, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA., Kaya F; Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Alland D; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.; Public Health Research Institute, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA., Zimmerman M; Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA., Nuermberger EL; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Jun 04; Vol. 69 (6), pp. e0013025. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-6596
DOI:10.1128/aac.00130-25