Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis.

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Title: Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis.
Authors: Koyanagi T; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Saga Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takahashi Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Tamura K; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Suizu E; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takahashi S; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Taneichi A; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takei Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Mizukami H; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Fujiwara H; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.
Source: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2025 Apr; Vol. 8 (4), pp. e70202.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2573-8348
DOI:10.1002/cnr2.70202