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Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis.

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Title: Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis.
Authors: Koyanagi T; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Saga Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takahashi Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Tamura K; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Suizu E; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takahashi S; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Taneichi A; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Takei Y; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Mizukami H; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan., Fujiwara H; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.
Source: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2025 Apr; Vol. 8 (4), pp. e70202.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Koyanagi+T%22">Koyanagi T</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Saga+Y%22">Saga Y</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+Y%22">Takahashi Y</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Tamura+K%22">Tamura K</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Suizu+E%22">Suizu E</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Taneichi+A%22">Taneichi A</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Takei+Y%22">Takei Y</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Mizukami+H%22">Mizukami H</searchLink>; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiwara+H%22">Fujiwara H</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101747728%22">Cancer reports (Hoboken, N.J.)</searchLink> [Cancer Rep (Hoboken)] 2025 Apr; Vol. 8 (4), pp. e70202.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Inc%22">John Wiley & Sons, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101747728 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2573-8348 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225738348%22">25738348 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Rep (Hoboken) <i>Subsets: </i>MEDLINE
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              Text: 2025 Apr
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