A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
Saved in:
| Title: | A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model. |
|---|---|
| Authors: | Pons-Grífols A; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Tarrés-Freixas F; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Pérez M; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain., Riveira-Muñoz E; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Raïch-Regué D; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Perez-Zsolt D; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Muñoz-Basagoiti J; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Tondelli B; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain., Pradenas E; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Izquierdo-Useros N; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., Capdevila S; Comparative Medicine and Bioimage Centre of Catalonia (CMCiB), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Vergara-Alert J; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain., Urrea V; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Carrillo J; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., Ballana E; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Forrow S; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain., Clotet B; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Segalés J; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Bellaterra, Spain., Trinité B; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Blanco J; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain. |
| Source: | MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0072025. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
Be the first to leave a comment!
