Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.
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| Title: | Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement. |
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| Authors: | Grima N; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Smith AN; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Shepherd CE; Neuroscience Research Australia, Randwick, NSW, 2031, Australia., Henden L; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Zaw T; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia., Carroll L; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia., Rowe DB; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Kiernan MC; Neuroscience Research Australia, Randwick, NSW, 2031, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia.; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia., Blair IP; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Williams KL; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia. kelly.williams@mq.edu.au. |
| Source: | Molecular neurodegeneration [Mol Neurodegener] 2025 Apr 25; Vol. 20 (1), pp. 40. Date of Electronic Publication: 2025 Apr 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1750-1326 |
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| DOI: | 10.1186/s13024-025-00820-5 |
