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Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.

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Title: Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.
Authors: Grima N; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Smith AN; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Shepherd CE; Neuroscience Research Australia, Randwick, NSW, 2031, Australia., Henden L; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Zaw T; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia., Carroll L; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia., Rowe DB; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Kiernan MC; Neuroscience Research Australia, Randwick, NSW, 2031, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia.; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia., Blair IP; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Williams KL; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia. kelly.williams@mq.edu.au.
Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Apr 25; Vol. 20 (1), pp. 40. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.
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  Data: <searchLink fieldCode="AU" term="%22Grima+N%22">Grima N</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Smith+AN%22">Smith AN</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Shepherd+CE%22">Shepherd CE</searchLink>; Neuroscience Research Australia, Randwick, NSW, 2031, Australia.<br /><searchLink fieldCode="AU" term="%22Henden+L%22">Henden L</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Zaw+T%22">Zaw T</searchLink>; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Carroll+L%22">Carroll L</searchLink>; Australian Proteome Research Facility, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Rowe+DB%22">Rowe DB</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Kiernan+MC%22">Kiernan MC</searchLink>; Neuroscience Research Australia, Randwick, NSW, 2031, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia.; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Blair+IP%22">Blair IP</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+KL%22">Williams KL</searchLink>; Macquarie University Motor Neuron Disease Research Centre, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia. kelly.williams@mq.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2025 Apr 25; Vol. 20 (1), pp. 40. <i>Date of Electronic Publication: </i>2025 Apr 25.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101266600 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217501326%22">17501326 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurodegener <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40275359
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        Value: 10.1186/s13024-025-00820-5
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              Text: 2025 Apr 25
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