Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading.

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Title: Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading.
Authors: Tang W; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Yin JB; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Lin RG; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Wu CY; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Huang JL; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Zhu JJ; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Yang LF; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Li GM; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Cai DZ; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Liu LL; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Liu YL; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Zhang HY; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.
Source: IScience [iScience] 2025 Mar 30; Vol. 28 (5), pp. 112131. Date of Electronic Publication: 2025 Mar 30 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.112131