Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading.
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| Title: | Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading. |
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| Authors: | Tang W; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Yin JB; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Lin RG; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Wu CY; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Huang JL; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Zhu JJ; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Yang LF; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Li GM; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Cai DZ; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Liu LL; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Liu YL; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China., Zhang HY; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China. |
| Source: | IScience [iScience] 2025 Mar 30; Vol. 28 (5), pp. 112131. Date of Electronic Publication: 2025 Mar 30 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40276767 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yin+JB%22">Yin JB</searchLink>; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; 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The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+LL%22">Liu LL</searchLink>; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+YL%22">Liu YL</searchLink>; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HY%22">Zhang HY</searchLink>; Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Mar 30; Vol. 28 (5), pp. 112131. <i>Date of Electronic Publication: </i>2025 Mar 30 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40276767 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.isci.2025.112131 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 112131 Titles: – TitleFull: Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tang W – PersonEntity: Name: NameFull: Yin JB – PersonEntity: Name: NameFull: Lin RG – PersonEntity: Name: NameFull: Wu CY – PersonEntity: Name: NameFull: Huang JL – PersonEntity: Name: NameFull: Zhu JJ – PersonEntity: Name: NameFull: Yang LF – PersonEntity: Name: NameFull: Li GM – PersonEntity: Name: NameFull: Cai DZ – PersonEntity: Name: NameFull: Liu LL – PersonEntity: Name: NameFull: Liu YL – PersonEntity: Name: NameFull: Zhang HY IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 03 Text: 2025 Mar 30 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2589-0042 Numbering: – Type: volume Value: 28 – Type: issue Value: 5 Titles: – TitleFull: IScience Type: main |
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