3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction.

Saved in:
Bibliographic Details
Title: 3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction.
Authors: Inoue FSR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil. Electronic address: fabricioseidyinoue@gmail.com., Concato-Lopes VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Bortoleti BTDS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Tomiotto-Pellissier F; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Gonçalves-Lens MD; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Morais-Valentim JMB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Machado RRB; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil., Santiago-Silva KM; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Bispo MLF; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Schirmann JG; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Barbosa-Dekker AM; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil., Dekker RFH; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil., Assis MCT; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Conchon-Costa I; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Mantovani MS; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil., Panis C; Laboratory of Tumor Biology, Center of Health Sciences, State University of Western Parana, Francisco Beltrão, PR, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Jun; Vol. 187, pp. 118082. Date of Electronic Publication: 2025 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118082