3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction.
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| Title: | 3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction. |
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| Authors: | Inoue FSR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil. Electronic address: fabricioseidyinoue@gmail.com., Concato-Lopes VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Bortoleti BTDS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Tomiotto-Pellissier F; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Gonçalves-Lens MD; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Morais-Valentim JMB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Machado RRB; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil., Santiago-Silva KM; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Bispo MLF; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Schirmann JG; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil., Barbosa-Dekker AM; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil., Dekker RFH; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil., Assis MCT; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Conchon-Costa I; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil., Mantovani MS; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil., Panis C; Laboratory of Tumor Biology, Center of Health Sciences, State University of Western Parana, Francisco Beltrão, PR, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil. |
| Source: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Jun; Vol. 187, pp. 118082. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40280030 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Inoue+FSR%22">Inoue FSR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil. Electronic address: fabricioseidyinoue@gmail.com.<br /><searchLink fieldCode="AU" term="%22Concato-Lopes+VM%22">Concato-Lopes VM</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Bortoleti+BTDS%22">Bortoleti BTDS</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Cruz+EMS%22">Cruz EMS</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Detoni+MB%22">Detoni MB</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Tomiotto-Pellissier+F%22">Tomiotto-Pellissier F</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves-Lens+MD%22">Gonçalves-Lens MD</searchLink>; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Morais-Valentim+JMB%22">Morais-Valentim JMB</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+RRB%22">Machado RRB</searchLink>; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Santiago-Silva+KM%22">Santiago-Silva KM</searchLink>; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Bispo+MLF%22">Bispo MLF</searchLink>; Laboratório de Síntese de Moléculas Medicinais (LaSMMed), Department of Chemistry, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Schirmann+JG%22">Schirmann JG</searchLink>; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa-Dekker+AM%22">Barbosa-Dekker AM</searchLink>; Laboratory of Research of Bioactive Molecules, Department of Chemistry, State University of Londrina, Londrina, PR, Brazil; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil.<br /><searchLink fieldCode="AU" term="%22Dekker+RFH%22">Dekker RFH</searchLink>; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24A - Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Londrina, PR CEP: 86036-700, Brazil.<br /><searchLink fieldCode="AU" term="%22Assis+MCT%22">Assis MCT</searchLink>; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Conchon-Costa+I%22">Conchon-Costa I</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Mantovani+MS%22">Mantovani MS</searchLink>; Laboratory of Toxicological Genetics, Department of General Biology, State University of Londrina, Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Lazarin-Bidóia+D%22">Lazarin-Bidóia D</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil; Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Panis+C%22">Panis C</searchLink>; Laboratory of Tumor Biology, Center of Health Sciences, State University of Western Parana, Francisco Beltrão, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Pavanelli+WR%22">Pavanelli WR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, PR, Brazil. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Jun; Vol. 187, pp. 118082. <i>Date of Electronic Publication: </i>2025 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40280030 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biopha.2025.118082 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 118082 Titles: – TitleFull: 3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Inoue FSR – PersonEntity: Name: NameFull: Concato-Lopes VM – PersonEntity: Name: NameFull: Bortoleti BTDS – PersonEntity: Name: NameFull: Cruz EMS – PersonEntity: Name: NameFull: Detoni MB – PersonEntity: Name: NameFull: Tomiotto-Pellissier F – PersonEntity: Name: NameFull: Gonçalves-Lens MD – PersonEntity: Name: NameFull: Morais-Valentim JMB – PersonEntity: Name: NameFull: Machado RRB – PersonEntity: Name: NameFull: Santiago-Silva KM – PersonEntity: Name: NameFull: Bispo MLF – PersonEntity: Name: NameFull: Schirmann JG – PersonEntity: Name: NameFull: Barbosa-Dekker AM – PersonEntity: Name: NameFull: Dekker RFH – PersonEntity: Name: NameFull: Assis MCT – PersonEntity: Name: NameFull: Conchon-Costa I – PersonEntity: Name: NameFull: Mantovani MS – PersonEntity: Name: NameFull: Lazarin-Bidóia D – PersonEntity: Name: NameFull: Panis C – PersonEntity: Name: NameFull: Pavanelli WR IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2025 Jun Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1950-6007 Numbering: – Type: volume Value: 187 Titles: – TitleFull: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Type: main |
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