JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production.

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Title: JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production.
Authors: Jeong PS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea., Yang HJ; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea., Park YH; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Jin YB; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea., Song BS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Hong JJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lee SH; Department of Life Science, Chung-Ang University, Seoul, Republic of Korea., Lee JH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lim KS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Jeong KJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Kang P; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Lee HY; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Son HC; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Kim HN; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea., Ha SM; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Hwang EH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Cha JJ; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Jung Y; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Research Institute, huMetaCELL Inc., Bucheon, Republic of Korea., Choi SA; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Companion Animals, Chungcheong University, Cheongju, Republic of Korea., Lee S; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea., Lee SR; Department of Pharmacology, Ajou University School of Medicine, Suwon, Republic of Korea., Lee SC; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea., Kang KS; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea; Department of Bio Life Sciences, Shingu College, Seongnam, Republic of Korea., Hur CG; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea., Jung YW; College of Pharmacy, Korea University, Sejong, Republic of Korea., Koo DB; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea., Choo YK; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea., Kim JM; Department of Pathology, Cancer Research Institute and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea., Sim BW; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: embryont@kribb.re.kr., Kim SU; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: sunuk@kribb.re.kr.
Source: Journal of advanced research [J Adv Res] 2026 Feb; Vol. 80, pp. 643-654. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2090-1224
DOI:10.1016/j.jare.2025.04.036