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JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production.

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Title: JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production.
Authors: Jeong PS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea., Yang HJ; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea., Park YH; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Jin YB; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea., Song BS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Hong JJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lee SH; Department of Life Science, Chung-Ang University, Seoul, Republic of Korea., Lee JH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lim KS; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Jeong KJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Kang P; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Lee HY; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Son HC; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Kim HN; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea., Ha SM; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Hwang EH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Cha JJ; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea., Jung Y; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Research Institute, huMetaCELL Inc., Bucheon, Republic of Korea., Choi SA; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Companion Animals, Chungcheong University, Cheongju, Republic of Korea., Lee S; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea., Lee SR; Department of Pharmacology, Ajou University School of Medicine, Suwon, Republic of Korea., Lee SC; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea., Kang KS; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea; Department of Bio Life Sciences, Shingu College, Seongnam, Republic of Korea., Hur CG; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea., Jung YW; College of Pharmacy, Korea University, Sejong, Republic of Korea., Koo DB; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea., Choo YK; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea., Kim JM; Department of Pathology, Cancer Research Institute and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea., Sim BW; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: embryont@kribb.re.kr., Kim SU; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: sunuk@kribb.re.kr.
Source: Journal of advanced research [J Adv Res] 2026 Feb; Vol. 80, pp. 643-654. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production.
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  Data: <searchLink fieldCode="AU" term="%22Jeong+PS%22">Jeong PS</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yang+HJ%22">Yang HJ</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+YH%22">Park YH</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jin+YB%22">Jin YB</searchLink>; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+BS%22">Song BS</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+JJ%22">Hong JJ</searchLink>; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+KS%22">Lim KS</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+KJ%22">Jeong KJ</searchLink>; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+P%22">Kang P</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HY%22">Lee HY</searchLink>; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+HC%22">Son HC</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HN%22">Kim HN</searchLink>; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ha+SM%22">Ha SM</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hwang+EH%22">Hwang EH</searchLink>; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cha+JJ%22">Cha JJ</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+Y%22">Jung Y</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Research Institute, huMetaCELL Inc., Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+SA%22">Choi SA</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Companion Animals, Chungcheong University, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SR%22">Lee SR</searchLink>; Department of Pharmacology, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SC%22">Lee SC</searchLink>; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+KS%22">Kang KS</searchLink>; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea; Department of Bio Life Sciences, Shingu College, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hur+CG%22">Hur CG</searchLink>; Bio Division, APURES Inc., Pyeongtaek, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+YW%22">Jung YW</searchLink>; College of Pharmacy, Korea University, Sejong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Koo+DB%22">Koo DB</searchLink>; Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choo+YK%22">Choo YK</searchLink>; Department of Biological Science, College of National Sciences, Wonkwang University, Iksan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JM%22">Kim JM</searchLink>; Department of Pathology, Cancer Research Institute and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sim+BW%22">Sim BW</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: embryont@kribb.re.kr.<br /><searchLink fieldCode="AU" term="%22Kim+SU%22">Kim SU</searchLink>; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea. Electronic address: sunuk@kribb.re.kr.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Feb; Vol. 80, pp. 643-654. <i>Date of Electronic Publication: </i>2025 Apr 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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