Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials.

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Title: Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials.
Authors: Samuels THA; Division of Infection and Immunity, University College London, London, UK., Molloy SF; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Loyse A; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Kanyama C; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi., Heyderman RS; Division of Infection and Immunity, University College London, London, UK; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Lai WS; National Institute for Health and Care Research Biomedical Research Centre Clinical and Research Informatics Unit, University College London Hospitals NHS Foundation Trust, London, UK., Mfinanga S; Division of Infection and Immunity, University College London, London, UK; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Lesikari S; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania., Chanda D; Institute for Medical Research and Training, Lusaka, Zambia; Department of International Medicine, University Teaching Hospital, Lusaka, Zambia., Kouanfack C; Department of Public Health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon; Research Center on Emerging and Re-emerging diseases, Yaoundé, Cameroon; Site Agence Nationale de Recherche sur le Sida Cameroun, Hôpital Central Yaoundé, Yaoundé, Cameroon., Temfack E; Molecular Mycology Unit, Institut Pasteur, Paris, France; Department of Internal Medicine, Douala General Hospital, Douala, Cameroon., Lortholary O; Department of Infectious Disease and Tropical Medicine, University of Paris, Paris, France; Department of Mycology, National Reference Center for Invasive Mycoses and Antifungals, Institut Pasteur, Paris, France; Institut Imagine, Necker Enfant Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Hosseinipour MC; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Chan AK; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Dignitas International, Zomba Central Hospital, Zomba, Malawi., Meya DB; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Boulware DR; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Mwandumba HC; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Meintjes G; Department of Medicine and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Muzoora C; Department of Internal Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Mosepele M; Botswana Harvard Health Partnership, Gaborone, Botswana; Department of Internal Medicine, University of Botswana, Gaborone, Botswana., Ndhlovu CE; Internal Medicine Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Youssouf N; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana., Harrison TS; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana., Gupta RK; UCL Respiratory Research Department, Division of Medicine, University College London, London, UK. Electronic address: r.gupta@ucl.ac.uk.
Source: The Lancet. Global health [Lancet Glob Health] 2025 May; Vol. 13 (5), pp. e920-e930.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2214-109X
DOI:10.1016/S2214-109X(25)00010-5