Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials.
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| Title: | Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials. |
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| Authors: | Samuels THA; Division of Infection and Immunity, University College London, London, UK., Molloy SF; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Loyse A; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Kanyama C; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi., Heyderman RS; Division of Infection and Immunity, University College London, London, UK; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Lai WS; National Institute for Health and Care Research Biomedical Research Centre Clinical and Research Informatics Unit, University College London Hospitals NHS Foundation Trust, London, UK., Mfinanga S; Division of Infection and Immunity, University College London, London, UK; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Lesikari S; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania., Chanda D; Institute for Medical Research and Training, Lusaka, Zambia; Department of International Medicine, University Teaching Hospital, Lusaka, Zambia., Kouanfack C; Department of Public Health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon; Research Center on Emerging and Re-emerging diseases, Yaoundé, Cameroon; Site Agence Nationale de Recherche sur le Sida Cameroun, Hôpital Central Yaoundé, Yaoundé, Cameroon., Temfack E; Molecular Mycology Unit, Institut Pasteur, Paris, France; Department of Internal Medicine, Douala General Hospital, Douala, Cameroon., Lortholary O; Department of Infectious Disease and Tropical Medicine, University of Paris, Paris, France; Department of Mycology, National Reference Center for Invasive Mycoses and Antifungals, Institut Pasteur, Paris, France; Institut Imagine, Necker Enfant Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Hosseinipour MC; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Chan AK; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Dignitas International, Zomba Central Hospital, Zomba, Malawi., Meya DB; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Boulware DR; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Mwandumba HC; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Meintjes G; Department of Medicine and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Muzoora C; Department of Internal Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Mosepele M; Botswana Harvard Health Partnership, Gaborone, Botswana; Department of Internal Medicine, University of Botswana, Gaborone, Botswana., Ndhlovu CE; Internal Medicine Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Youssouf N; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana., Harrison TS; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana., Gupta RK; UCL Respiratory Research Department, Division of Medicine, University College London, London, UK. Electronic address: r.gupta@ucl.ac.uk. |
| Source: | The Lancet. Global health [Lancet Glob Health] 2025 May; Vol. 13 (5), pp. e920-e930. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40288401 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Personalised risk-prediction tools for cryptococcal meningitis mortality to guide treatment stratification in sub-Saharan Africa: a prognostic modelling study based on pooled analysis of two randomised controlled trials. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Samuels+THA%22">Samuels THA</searchLink>; Division of Infection and Immunity, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Molloy+SF%22">Molloy SF</searchLink>; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lawrence+DS%22">Lawrence DS</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Loyse+A%22">Loyse A</searchLink>; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kanyama+C%22">Kanyama C</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi.<br /><searchLink fieldCode="AU" term="%22Heyderman+RS%22">Heyderman RS</searchLink>; Division of Infection and Immunity, University College London, London, UK; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Lai+WS%22">Lai WS</searchLink>; National Institute for Health and Care Research Biomedical Research Centre Clinical and Research Informatics Unit, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Mfinanga+S%22">Mfinanga S</searchLink>; Division of Infection and Immunity, University College London, London, UK; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lesikari+S%22">Lesikari S</searchLink>; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22Chanda+D%22">Chanda D</searchLink>; Institute for Medical Research and Training, Lusaka, Zambia; Department of International Medicine, University Teaching Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Kouanfack+C%22">Kouanfack C</searchLink>; Department of Public Health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon; Research Center on Emerging and Re-emerging diseases, Yaoundé, Cameroon; Site Agence Nationale de Recherche sur le Sida Cameroun, Hôpital Central Yaoundé, Yaoundé, Cameroon.<br /><searchLink fieldCode="AU" term="%22Temfack+E%22">Temfack E</searchLink>; Molecular Mycology Unit, Institut Pasteur, Paris, France; Department of Internal Medicine, Douala General Hospital, Douala, Cameroon.<br /><searchLink fieldCode="AU" term="%22Lortholary+O%22">Lortholary O</searchLink>; Department of Infectious Disease and Tropical Medicine, University of Paris, Paris, France; Department of Mycology, National Reference Center for Invasive Mycoses and Antifungals, Institut Pasteur, Paris, France; Institut Imagine, Necker Enfant Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hosseinipour+MC%22">Hosseinipour MC</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi; Department of Medicine, Kamuzu Central Hospital, Lilongwe, Malawi; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chan+AK%22">Chan AK</searchLink>; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Dignitas International, Zomba Central Hospital, Zomba, Malawi.<br /><searchLink fieldCode="AU" term="%22Meya+DB%22">Meya DB</searchLink>; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Boulware+DR%22">Boulware DR</searchLink>; Department of Medicine, School of Medicine, Makerere University, Kampala, Uganda; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mwandumba+HC%22">Mwandumba HC</searchLink>; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Meintjes+G%22">Meintjes G</searchLink>; Department of Medicine and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Muzoora+C%22">Muzoora C</searchLink>; Department of Internal Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Mosepele+M%22">Mosepele M</searchLink>; Botswana Harvard Health Partnership, Gaborone, Botswana; Department of Internal Medicine, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Ndhlovu+CE%22">Ndhlovu CE</searchLink>; Internal Medicine Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Youssouf+N%22">Youssouf N</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Harrison+TS%22">Harrison TS</searchLink>; Centre for Global Health, Institute for Infection and Immunity, City St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+JN%22">Jarvis JN</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Gupta+RK%22">Gupta RK</searchLink>; UCL Respiratory Research Department, Division of Medicine, University College London, London, UK. Electronic address: r.gupta@ucl.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101613665%22">The Lancet. Global health</searchLink> [Lancet Glob Health] 2025 May; Vol. 13 (5), pp. e920-e930. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101613665 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2214-109X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222214109X%22">2214109X </searchLink><i>NLM ISO Abbreviation: </i>Lancet Glob Health <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40288401 |
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